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<!-- EDGAR Online I-Metrix Xcelerate Taxonomy Schema, based on XBRL 2.1  http://www.edgar-online.com/ -->
<!-- Version: 6.13.8 -->
<!-- Round: 1 -->
<!-- Creation date: 2012-02-25T02:22:53Z -->
<!-- Copyright (c) 2005-2011 EDGAR Online, Inc. All Rights Reserved. -->
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      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/DocumentDocumentandEntityInformation" id="DocumentDocumentandEntityInformation">
        <link:definition>101 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/StatementOfFinancialPositionClassified" id="Role_StatementOfFinancialPositionClassified">
        <link:definition>103 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/StatementOfFinancialPositionClassifiedParenthetical" id="Role_StatementOfFinancialPositionClassifiedParen">
        <link:definition>104 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/StatementOfIncome" id="Role_StatementOfIncome">
        <link:definition>105 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>106 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS' EQUITY (CAPITAL DEFICIENCY)</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>107 - Statement - CONSOLIDATED STATEMENT OF CHANGES IN SHAREHOLDERS' EQUITY (CAPITAL DEFICIENCY) (Parenthetical)</link:definition>
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        <link:definition>108 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>109 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>110 - Disclosure - LICENSE AND SUPPLY AGREEMENT</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>111 - Disclosure - PROPERTY AND EQUIPMENT</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
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      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/NotesToFinancialStatementsInventoryDisclosureTextBlock" id="Role_NotesToFinancialStatementsInventoryDisclosureTextBlock">
        <link:definition>112 - Disclosure - INVENTORIES</link:definition>
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        <link:definition>113 - Disclosure - LIABILITY FOR EMPLOYEE RIGHTS UPON RETIREMENT</link:definition>
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        <link:usedOn>link:presentationLink</link:usedOn>
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        <link:definition>114 - Disclosure - COMMITMENTS</link:definition>
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        <link:definition>115 - Disclosure - SHARE CAPITAL</link:definition>
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        <link:definition>116 - Disclosure - TAXES ON INCOME</link:definition>
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      <link:roleType roleURI="http://www.protalix.com/taxonomy/role/NotesToFinancialStatementsAdditionalFinancialInformationDisclosureTextBlock" id="Role_NotesToFinancialStatementsAdditionalFinancialInformationDisclosureTextBlock">
        <link:definition>117 - Disclosure - SUPPLEMENTARY FINANCIAL STATEMENT INFORMATION</link:definition>
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        <link:definition>118 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
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        <link:definition>119 - Disclosure - SUBSEQUENT EVENTS</link:definition>
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