Document and Entity Information
Document Type
Document Annual Report
Document Period End Date
Document Transition Report
Securities Act File Number
Entity Registrant Name
Entity Incorporation, State or Country Code
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Postal Zip Code
City Area Code
Local Phone Number
Title of 12(b) Security
Trading Symbol
Security Exchange Name
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
ICFR Auditor Attestation Flag
Document Financial Statement Error Correction [Flag]
Entity Shell Company
Entity Public Float
Entity Common Stock, Shares Outstanding
Entity Central Index Key
Current Fiscal Year End Date
Document Fiscal Year Focus
Document Fiscal Period Focus
Amendment Flag
Entity Voluntary Filers
Entity Well-known Seasoned Issuer
Auditor Name
Auditor Firm ID
Auditor Location
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
CONSOLIDATED BALANCE SHEETS
Statement [Table]
Statement [Line Items]
Assets [Abstract]
ASSETS
Assets, Current [Abstract]
CURRENT ASSETS:
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Carrying value of deposits held with banks for short period, usually less than one year or the normal operating cycle, whichever is longer.
Short-term Bank Deposits
Short-term bank deposits
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable - Trade
Other Assets, Current
Other assets
Other assets
Inventory, Net
Inventories
Total inventory
Assets, Current
Total current assets
Assets, Noncurrent [Abstract]
NON-CURRENT ASSETS:
Assets for Plan Benefits, Defined Benefit Plan
Funds in respect of employee rights upon retirement
Property, Plant and Equipment, Net
Property and equipment, net
Property, plant and equipment, net, total
Deferred Income Tax Assets, Net
Deferred income tax asset
Operating Lease, Right-of-Use Asset
Operating lease right of use assets
Assets
Total assets
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities, Current [Abstract]
CURRENT LIABILITIES:
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable and accruals:
Accounts payable and accruals - other:
Accounts Payable, Trade, Current
Trade
Sum of the carrying values as of the balance sheet date of other obligations incurred through that date and due within one year (or the operating cycle, if longer).
Accounts Payable and Accrued Liabilities, Other, Current
Other
Accounts payable and accruals - other
Operating Lease, Liability, Current
Operating lease liabilities
Convertible Debt, Current
Convertible notes
Liabilities, Current
Total current liabilities
Liabilities, Noncurrent [Abstract]
LONG TERM LIABILITIES:
Liability, Pension and Other Postretirement and Postemployment Benefits, Noncurrent
Liability for employee rights upon retirement
Operating Lease, Liability, Noncurrent
Operating lease liabilities
Liabilities, Noncurrent
Total long term liabilities
Liabilities
Total liabilities
Commitments and Contingencies
COMMITMENTS
Equity, Attributable to Parent [Abstract]
STOCKHOLDERS' EQUITY
Common Stock, Value, Issued
Common Stock, $0.001 par value: Authorized - as of December 31, 2023 and 2024, 185,000,000 shares; issued and outstanding - as of December 31, 2023 and 2024, 72,952,124 and 75,850,275 shares, respectively
Additional Paid in Capital, Common Stock
Additional paid-in capital
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Equity, Attributable to Parent
Ending balance
Beginning balance
Total stockholders' equity
Liabilities and Equity
Total liabilities and stockholders' equity
Common Stock, Par or Stated Value Per Share
Common Stock, Par or Stated Value Per Share (in dollars per share)
Common Stock, Shares Authorized
Common Stock, Shares Authorized
Common stock, authorized
Common Stock, Shares, Issued
Ending balance (in shares)
Beginning balance (in shares)
Common Stock, issued
Common Stock, Shares, Outstanding
Common Stock, outstanding
CONSOLIDATED STATEMENTS OF OPERATIONS
Product and Service [Axis]
Product and Service [Domain]
Product [Member]
GOODS
Goods
License and Service [Member]
LICENSE AND R&D SERVICES
License and R&D Services
Revenues.
TOTAL REVENUE
Revenues from customers
Cost of Revenue
COST OF GOODS SOLD
Research and Development Expense
RESEARCH AND DEVELOPMENT EXPENSES
Selling, General and Administrative Expense
SELLING, GENERAL AND ADMINISTRATIVE EXPENSES
Operating Income (Loss)
OPERATING INCOME (LOSS)
Other Nonoperating Expense
FINANCIAL EXPENSES
interest expense
Other Nonoperating Income
Interest income
FINANCIAL INCOME
Nonoperating Income (Expense)
FINANCIAL INCOME (EXPENSES), NET
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
INCOME (LOSS) BEFORE TAXES ON INCOME
Income Tax Expense (Benefit)
TAXES ON INCOME
Income tax expenses
Total taxes on income
NET INCOME (LOSS)
Net income (loss)
Earnings Per Share, Basic
EARNINGS (LOSS) PER SHARE OF COMMON STOCK - BASIC (in dollars per share)
Earnings Per Share, Diluted
EARNINGS (LOSS) PER SHARE OF COMMON STOCK - DILUTED (in dollars per share)
Weighted Average Number of Shares Outstanding, Basic
WEIGHTED AVERAGE NUMBER OF SHARES OF COMMON STOCK USED IN COMPUTING EARNINGS (LOSS) PER SHARE - BASIC (in shares)
Weighted average shares of Common Stock outstanding for basic calculation
Weighted Average Number of Shares Outstanding, Diluted
WEIGHTED AVERAGE NUMBER OF SHARES OF COMMON STOCK USED IN COMPUTING EARNINGS (LOSS) PER SHARE - DILUTED (in shares)
Weighted average shares of Common Stock outstanding for diluted calculation
CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY (CAPITAL DEFICIENCY)
Equity Components [Axis]
Equity Component [Domain]
Common Stock [Member]
Common Stock
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Retained Earnings [Member]
Accumulated Deficit
Accounting Standards Update [Axis]
Accounting Standards Update [Domain]
Accounting Standards Update 2020-06 [Member]
ASU 2020-06
Cumulative Effect, Period of Adoption [Axis]
Cumulative Effect, Period of Adoption [Domain]
Cumulative Effect, Period of Adoption, Adjustment [Member]
Adjustment
Effect of Change
Stock Issued During Period, Value, New Issues
Issuance of common stock, net of issuance cost
Stock Issued During Period, Shares, New Issues
Issuance of common stock, net of issuance cost (in shares)
Number of shares issued (in shares)
Equity impact of the value of new stock issued during the period. Includes shares issued in a sales agreement.
Stock Issued During Period, Value, Sales Agreement
Issuance of common stock under the Sales Agreement, net
Stock Issued During Period, Shares, Sales Agreement
Stock Issued During Period, Shares, Sales Agreement
Issuance of common stock under the Sales Agreement, net (in shares)
Stock Issued During Period, Value, Conversion of Convertible Securities
Convertible notes conversions
Stock Issued During Period, Shares, Conversion of Convertible Securities
Convertible notes conversions (in shares)
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Share-based compensation related to stock options
Amount of recognized equity-based compensation during the period for restricted stock awards.
Share Based Compensation Restricted Stock Awards Net Of Forfeitures
Share-based compensation related to restricted stock awards
Share Based Compensation Restricted Stock Awards Net Of Forfeitures Shares
Share Based Compensation Restricted Stock Awards Net Of Forfeitures Shares
Share-based compensation related to restricted stock awards (in shares)
Value of shares issued during period for exercise of warrants.
Stock Issued During Period, Value, Warrants Exercises
Exercise of warrants
Number of shares issued during period for exercise of warrants.
Stock Issued During Period, Shares, Warrants Exercises
Exercise of warrants (in shares)
CONSOLIDATED STATEMENTS OF CASH FLOWS
Net Cash Provided by (Used in) Operating Activities [Abstract]
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net income (loss)
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments required to reconcile net income (loss) to net cash provided by (used in) operating activities:
Share-Based Payment Arrangement, Noncash Expense
Share-based compensation
Depreciation
Depreciation
Depreciation
Unrealized Gain (Loss), Foreign Currency Transaction, before Tax
Financial income, net
Pension and Other Postretirement Benefits Cost (Reversal of Cost)
Changes in accrued liability for employee rights upon retirement
Deferred Income Tax Expense (Benefit)
Changes in deferred income tax asset
Deferred taxes on income
Gain (loss) on amounts funded in respect of employee rights upon retirement.
Gain Loss On Amounts Funded In Respect Of Employee Rights Upon Retirement
Loss (gain) on amounts funded in respect of employee rights upon retirement
Gain (Loss) on Disposition of Property Plant Equipment
Loss (gain) on sale of fixed assets
The amount of gain (loss) on conversion of convertible debt.
Gain (Loss) On Debt Conversion
Gain on conversions of convertible notes
Amortization of Debt Issuance Costs and Discounts
Amortization of debt issuance costs and debt discount
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Increase (Decrease) in Contract with Customer, Liability
Decrease in contracts liability
Increase (Decrease) in Accounts Receivable
Decrease (increase) in accounts receivable-trade and other assets
Amount of Net Change in Operating Lease Right Of use Assets.
Change in Operating Lease Right Of use Assets
Changes in operating lease right of use assets, net
Increase (Decrease) in Inventories
Decrease (increase) in inventories
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Increase (decrease) in accounts payable and accruals
Net Cash Provided by (Used in) Operating Activities
Net cash provided by (used in) operating activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
CASH FLOWS FROM INVESTING ACTIVITIES:
Amount of increase (decrease) in deposits held with banks.
Increase (Decrease) in Bank Deposits
Investment in bank deposits
The amount of cash inflow from the withdrawal of short-term deposits during the period.
Proceeds From Withdrawal Of Short-Term Deposits
Short-term deposit withdrawal
Payments to Acquire Property, Plant, and Equipment
Purchase of property and equipment
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from sale of property and equipment
Payments for (Proceeds from) Other Investing Activities
Amounts paid (funded) in respect of employee rights upon retirement, net
Net Cash Provided by (Used in) Investing Activities
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
CASH FLOWS FROM FINANCING ACTIVITIES:
Repayments of Convertible Debt
Payment for convertible notes redemption
Repayments of Notes Payable
Payment for promissory note
Payment for promissory note
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock under the Sales Agreement, net
Stock issuance proceeds
Proceeds from Warrant Exercises
Exercise of warrants
Net Cash Provided by (Used in) Financing Activities
Net cash provided by (used in) financing activities
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
EFFECT OF EXCHANGE RATE CHANGES ON CASH AND CASH EQUIVALENTS
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
BALANCE OF CASH AND CASH EQUIVALENTS AT END OF YEAR
BALANCE OF CASH AND CASH EQUIVALENTS AT BEGINNING OF YEAR
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
SUPPLEMENTARY INFORMATION ON INVESTING AND FINANCING ACTIVITIES NOT INVOLVING CASH FLOWS:
Capital Expenditures Incurred but Not yet Paid
Purchase of property and equipment
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease right of use assets obtained in exchange for new operating lease liabilities
Debt Conversion, Converted Instrument, Amount
Convertible notes conversions
The amount of partial settlement of liability for employee rights upon retirement through transfer of related funds in non-cash financing and investing activities.
Partial Settlement Of Liability For Employee Rights Upon Retirement Through Transfer Of the Related Funds
Partial settlement of liability for employee rights upon retirement through transfer of the related funds
Supplemental Cash Flow Information [Abstract]
SUPPLEMENTARY DISCLOSURE ON CASH FLOWS
Income Taxes Paid, Net
Tax paid
Interest Paid, Excluding Capitalized Interest, Operating Activities
Interest paid
Amount of cash received for interest.
Interest Received, Net
Interest received
SIGNIFICANT ACCOUNTING POLICIES
Basis of Presentation and Significant Accounting Policies [Text Block]
SIGNIFICANT ACCOUNTING POLICIES
COMMERCIALIZATION AGREEMENTS
Collaborative Arrangement Disclosure [Text Block]
COMMERCIALIZATION AGREEMENTS
PROPERTY AND EQUIPMENT
Property, Plant and Equipment Disclosure [Text Block]
PROPERTY AND EQUIPMENT
INVENTORIES
Inventory Disclosure [Text Block]
INVENTORIES
LIABILITY FOR EMPLOYEE RIGHTS UPON RETIREMENT
Retirement Benefits [Text Block]
LIABILITY FOR EMPLOYEE RIGHTS UPON RETIREMENT
COMMITMENTS
Commitments Disclosure [Text Block]
COMMITMENTS
OPERATING LEASES
Lessee, Operating Leases [Text Block]
OPERATING LEASES
SHARE CAPITAL
Equity [Text Block]
SHARE CAPITAL
CONVERTIBLE NOTES
Debt Disclosure [Text Block]
CONVERTIBLE NOTES
FAIR VALUE MEASUREMENT
Fair Value Disclosures [Text Block]
FAIR VALUE MEASUREMENT
NET EARNINGS (LOSS) PER SHARE
Earnings Per Share [Text Block]
NET EARNINGS (LOSS) PER SHARE
TAXES ON INCOME
Income Tax Disclosure [Text Block]
TAXES ON INCOME
SEGMENT INFORMATION
Segment Reporting Disclosure [Text Block]
SEGMENT INFORMATION
SUPPLEMENTARY FINANCIAL STATEMENT INFORMATION
Additional Financial Information Disclosure [Text Block]
SUPPLEMENTARY FINANCIAL STATEMENT INFORMATION
RELATED PARTY TRANSACTIONS
Related Party Transactions Disclosure [Text Block]
RELATED PARTY TRANSACTIONS
SUBSEQUENT EVENTS
Subsequent Events [Text Block]
SUBSEQUENT EVENTS
Nature Of Operations Policy
Nature Of Operations [Policy Text Block]
General
Basis of Accounting, Policy [Policy Text Block]
Basis of presentation
Use of Estimates, Policy [Policy Text Block]
Use of estimates in the preparation of financial statements
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Functional currency
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash equivalents
Accounts Receivable [Policy Text Block]
Accounts Receivables
Inventory, Policy [Policy Text Block]
Inventories
Property, Plant and Equipment, Policy [Policy Text Block]
Property and equipment
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment in value of long-lived assets
Income Tax, Policy [Policy Text Block]
Income taxes
Revenue [Policy Text Block]
Revenue recognition
Research and Development Expense, Policy [Policy Text Block]
Research and development costs
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of credit risks and trade receivable
Share-Based Payment Arrangement [Policy Text Block]
Share-based compensation
Earnings Per Share, Policy [Policy Text Block]
Net earnings (loss) per share
Debt, Policy [Policy Text Block]
Convertible notes
Lessee, Leases [Policy Text Block]
Leases
New Accounting Pronouncements, Policy [Policy Text Block]
New accounting pronouncements
Schedule Of Useful Life Table Text Block
Schedule Of Useful Life [Table Text Block]
Schedule of Useful Life
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Schedule of ASU 2020-06 Impact to the Consolidated Balance Sheet
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment
Schedule of Inventory, Current [Table Text Block]
Schedule of Inventory
Lease, Cost [Table Text Block]
Schedule of Operating Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Maturity Analysis of Operating Leases
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Activity
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]
Summary of Share Options Outstanding and Exercisable
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Stock Option Valuation Assumptions
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Stock-Based Compensation Expense in Statement of Operations
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Represents information pertaining to convertible notes due 2021 and 2024.
Notes 2021 and 2024
Represents the information pertaining to seven point five percentage senior secured convertible notes due 2024.
2024 Notes
Interest Income and Interest Expense Disclosure [Table Text Block]
Schedule of Interest Expense Recognized
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Basic and Diluted Net Earnings (Loss) per Share
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Taxes on Income
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Tax Assets
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of Tax Expense
Summary of Valuation Allowance [Table Text Block]
Schedule of Company's Valuation Allowance
Summary of Income Tax Contingencies [Table Text Block]
Schedule of Reconciliation of the Beginning and Ending Amount of Unrecognized Tax Benefits
Schedule Of Open Tax Years Table Text Block
Schedule Of Open Tax Years [Table Text Block]
Schedule of Open Tax Years
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Schedule of Segment Information
Revenue from External Customers by Products and Services [Table Text Block]
Schedule of Disaggregation of Revenues
The tabular disclosure for supplemental balance sheets information.
Supplementary Balance Sheets Information [Table Text Block]
Schedule of Supplemental Information of Balance Sheets
Schedule of Related Party Transactions [Table Text Block]
Schedule of Related Party Transactions
Significant Accounting Policies [Table].
Significant Accounting Policies [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Amended Pfizer Agreement [Member]
Amended Pfizer Agreement
Chiesi Agreements [Member]
Chiesi Agreements
Chiesi Agreements
Legal Entity [Axis]
All Entities [Member]
Protalix Bio Therapeutics Incorporation [Member].
Protalix Bio Therapeutics Incorporation
Geographical [Axis]
Geographical [Domain]
BRAZIL
Brazil
Significant Accounting Policies [Line Items]
SIGNIFICANT ACCOUNTING POLICIES
Represents the number of global licensing and supply agreements.
Number Of Global Licensing And Supply Agreements
Number of global licensing and supply agreements
Amount of milestone payment received upon achievement of certain milestone.
Milestone Payment Received
Amount of milestone payment received
Collaborative arrangement revenues and expense sharing percentage.
Collaborative Arrangement Revenues Expenses Sharing Percentage
Collaborative arrangement revenues and expenses sharing percentage
Revenue, Performance Obligation, Number
Revenue, Performance Obligation, Number
Performance obligation number
Accounts Receivable, Allowance for Credit Loss, Writeoff
Accounts receivables write-off
Accounts Receivable, Allowance for Credit Loss, Recovery
Accounts receivables recoveries
Debt Instrument, Interest Rate, Stated Percentage
Interest rate
Interest rate (as a percent)
Property, Plant and Equipment [Table]
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Domain]
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Laboratory equipment
Furniture and Fixtures [Member]
Furniture
Computer Equipment [Member]
Computer equipment
Statistical Measurement [Axis]
Statistical Measurement [Domain]
Minimum [Member]
Minimum
Maximum [Member]
Maximum
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life
Property and equipment, useful life
Customer [Axis]
Customer [Domain]
Fiocruz
Global except Brazil and Italy
Chiesi
Global except for Brazil
Pfizer
Cumulative Effect, Period of Adoption, Adjusted Balance [Member]
Cumulative Effect, Period of Adoption, Adjusted Balance
Chiesi US Agreement
Chiesi Ex-US Agreement
The amount of upfront, non refundable and non creditable payment receivable under the agreement for licensing rights.
Upfront Nonrefundable Non creditable Payment Receivable
Non-refundable payment receivable
The maximum amount payable to the entity to cover development costs under agreement.
Additional Amounts Payable To Cover Development Costs
Additional amounts payable to cover development costs
The maximum amount payable to entity to cover development costs in any year under agreement.
Maximum Entitlement Of Development Costs To Cover Per Year
Maximum entitlement of development costs to cover per year
The total amount payable to entity for the achievement of regulatory and commercial milestones.
Additional Amount Payable For Achievement Of Regulatory And Commercial Milestones
Additional amount payable for achievement of regulatory and commercial milestones
Represents the payment as a percentage of future net sales.
Payment On Net Sales Percentage
Payment on net sales percentage
Furniture And Computer Equipment Member
Furniture And Computer Equipment [Member]
Furniture and computer equipment
Leasehold Improvements [Member]
Leasehold improvements
Property, Plant and Equipment, Gross
Property, plant and equipment, gross
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less - accumulated depreciation and amortization
Inventory, Raw Materials, Net of Reserves
Raw materials
Inventory, Work in Process, Net of Reserves
Work in progress
Inventory, Finished Goods, Net of Reserves
Finished goods
Inventory Write-down
Inventory write-down
Retirement Plan Type [Axis]
Retirement Plan Type [Domain]
Postretirement Life Insurance [Member]
Contribution to Insurance Companies
Contribution to Defined Contribution Plans [Member]
Contribution to Defined Contribution Plans
Employee severance obligation payment.
Employee Severance Obligation Payment
Employee severance obligation payments
Postemployment Benefits, Period Expense
Severance expense
Defined Contribution Plan, Employer Discretionary Contribution Amount
Contributions
Other Comprehensive Income (Loss), Defined Benefit Plan, Gain (Loss), after Reclassification Adjustment, before Tax
Gain for the period
Defined Benefit Plan, Expected Future Employer Contributions, Next Fiscal Year
Contribution in connection with severance liabilities
Number Of Employees To Receive Benefits During Next Five Years
Number Of Employees To Receive Benefits During Next Five Years
Number of benefit eligible employees
Research and Development, Contract to Perform for Others [Table]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Royalty Agreement Terms [Member]
Royalty Agreement Terms
Counterparty Name [Axis]
Counterparty Name [Domain]
Office of the Israeli Innovation Authority [Member]
Office of the Israeli Innovation Authority [Member]
Office of the Israeli Innovation Authority
Fill/Finish Agreement [Member]
Fill/Finish Agreement
Arrangement Other than Collaborative [Member]
Arrangement Other than Collaborative
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Percentage of royalties based on sale of products developed from projects funded.
Royalties On Sale Of Products
Royalties based on sale of products developed from funded projects, percentage
Required royalty payments represented as a percentage to grants received.
Percentage of Royalties to Grant Received
Percentage of Royalties to Grant Received
Royalty Expense
Royalty expense included in cost of revenue
Accrued Royalties
Accrued royalties
Commitment amount.
Commitment Amount
Subcontracting commitment amount
Extended term of agreement.
Extended Term Of Agreement
Extended term of agreement
Amount agreed to pay under the agreement.
Contract Amount Under Agreement, Payable
Contract amount
This represents the share of payment to a contract research organization to cover proportionate share of the costs in setting up a facility. May include equipment purchases but also other facility customization efforts, etc., none of which will be owned by the Company.
Contract Amount Under Agreement, Facility, Payable
Contracted share of facility cost amount
Initial term of arrangement.
Initial Term Of Arrangement
Initial term of arrangement
Disclosure of Leases Operating
Disclosure of Leases Operating [Line Items]
Operating Lease, Cost
Operating lease costs
Operating Lease, Payments
Cash paid for amounts included in the measurement of lease liabilities
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term (in years)
Operating Lease, Weighted Average Discount Rate, Percent
Weighted average discount rate
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
2026
Lessee, Operating Lease, Liability, to be Paid, Year Three
2027
Lessee, Operating Lease, Liability, to be Paid, Year Four
2028
Lessee, Operating Lease, Liability, to be Paid, after Year Five
2029 and thereafter
Lessee, Operating Lease, Liability, to be Paid
Total undiscounted cash flows
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Operating Lease, Liability
Present value of operating lease liabilities
Lessee, Lease, Description [Table]
Vehicles [Member]
Vehicles
Lessee, Operating Lease, Option to Extend
Option to extend
Lessee Operating Lease, Number Of Renewal Term Extensions
Lessee Operating Lease, Number Of Renewal Term Extensions
Operating lease, Renewable term
Lessee, Operating Lease, Renewal Term
Operating lease, term of agreement
Security Deposit
Cash deposited as bank guarantee
Percentage of Change in Operating Lease Monthly Rental Payments.
Percentage of Change in Operating Lease Monthly Rental Payments
Percentage of change in operating lease monthly rental payments
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Title and Position [Axis]
Title and Position [Domain]
Represents information pertaining to employees and directors.
Employees and Directors [Member]
Employees and directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Outstanding at end of year
Outstanding at beginning of year
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Expired (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Exercisable at end of year
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding at end of year
Outstanding at beginning of year
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Exercisable at end of year
Employee [Member]
Employee
Employee
Restricted Stock [Member]
Restricted Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Non vested at end of year
Outstanding at beginning of year
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Non vested at end of year
Outstanding at beginning of year
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Share-Based Payment Arrangement, Option, Exercise Price Range [Table]
Exercise Price Range [Axis]
Exercise Price Range [Domain]
Represents the information pertaining to exercise price ranging from $1.03 to $2.00.
Exercise Price 1.03 to 2.00 [Member]
$1.03 - $2.00
Represents the information pertaining to exercise price ranging from $3.55 to $3.73.
Exercise Price 3.55 to 3.73 [Member]
$3.55 - $3.73
Represents the information pertaining to exercise price ranging from $4.69 to $5.60.
Exercise Price 4.69 to 5.60 [Member]
$4.69 - $5.60
Represents the information pertaining to exercise price $17.20.
Exercise Price 17.20
$17.20
Share-Based Payment Arrangement, Option, Exercise Price Range [Line Items]
Share-Based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit
Exercise price, lower range
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit
Exercise price, upper range
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Outstanding
Number of options outstanding at end of year
Share-Based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Remaining Contractual Term
Weighted average remaining contractual life
Share-Based Payment Arrangement, Option, Exercise Price Range, Shares Exercisable
Number of options exercisable
Share-Based Payment Arrangement, Option, Exercise Price Range, Exercisable, Weighted Average Remaining Contractual Term
Weighted average remaining contractual life
Share Price
Weighted average grants date fair value (USD)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Exercise price (USD)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk free rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected life (Years)
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Domain]
Cost of Sales [Member]
Cost of goods sold
Research and Development Expense [Member]
Research and development expenses
Selling, General and Administrative Expenses [Member]
Selling, general and administrative expenses
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-Based Payment Arrangement, Expense
Share-based compensation expense
Represents information pertaining to stock options and restricted shares.
Options and Restricted Shares [Member]
Options and restricted shares
Sale of Stock [Axis]
Sale of Stock [Domain]
Private Placement [Member]
Private Placement
Represents the information pertaining to At The Market equity offering.
ATM Shares
ATM Shares
Represents information pertaining to 2021 Sales Agreement.
Sales Agreement 2021 [Member]
2021 Sales Agreement
Represents information pertaining to 2023 Sales Agreement.
Sales Agreement 2023 [Member]
2023 Sales Agreement
Plan Name [Axis]
Plan Name [Domain]
It represent the employee stock incentive plan for the particular period.
2006 Employee Stock Incentive Plan
Plan
Represents the information pertaining to 2024 notes.
Notes 2024 [Member]
2024 Notes
Preferred Stock, Shares Authorized
Preferred stock, authorized
Preferred Stock, Par or Stated Value Per Share
Preferred stock par value
Represents the number of votes for each share of common stock is entitled.
Common Stock, Number Of Voting Rights
Number of voting rights
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares authorized for issuance under share-based payment arrangement
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares of Common Stock remain available for grant under the plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Term of award
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Vesting-date fair value of stock vested
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized weighted average period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding options intrinsic value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Exercisable options intrinsic value
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of warrants issued (in shares)
Sale of stock, maximum offering price.
Sale Of Stock Maximum Offering Price
Sale of stock, maximum offering price
Percentage of commission on sale of shares.
Percentage of Commission on Sale of Shares
Commission (as a percent)
Payments of Stock Issuance Costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Debt Conversion, Converted Instrument, Shares Issued
Converted instrument, shares issued
The cash outflow to debt holders on conversion for accrued but unpaid interest, make-whole interest payments and payments in lieu of fractional shares.
Payments To Debt Holders On Conversion
Paid to the converting holders
Interest Expense, Debt, Excluding Amortization
Contractual interest expense
Interest Costs Incurred
Total
Debt Instrument, Term
Mature term
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Outstanding stock options and warrants.
Outstanding Stock Options And Warrants
Outstanding stock options and warrants and 2024 notes.
Outstanding Stock Options Warrants And 2024 Notes
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
NET EARNINGS (LOSS) PER SHARE
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Dilutive Securities, Effect on Basic Earnings Per Share
Financial expenses of 2024 Notes
Net Income (Loss) Available to Common Stockholders, Diluted
Net income (loss) for diluted calculation
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities
Weighted average dilutive effect of 2024 Notes
Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements
Weighted average dilutive effect of stock options and restricted stock
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of earnings per share, amount
Current Income Tax Expense (Benefit)
Current taxes on income
Components of Deferred Tax Assets and Liabilities [Abstract]
In respect of:
Deferred Tax Asset, In-Process Research and Development
Research and development expenses
The amount of deferred tax assets other timing differences.
Deferred Tax Assets Other Timing Differences
Other timing differences
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carry forwards
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Ending Balance
Beginning Balance
Deferred Tax Assets, Net of Valuation Allowance
Total net deferred tax assets
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Tax computed at the statutory U.S. income tax rate
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Differences in tax rate
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount
Statutorily non-deductible expenses
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Valuation allowance related to deferred tax assets
Change in Valuation allowances
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to utilization of carry-forward losses and other temporary items without deferred taxes recognition.
Effective Income Tax Rate Reconciliation, Utilization Of Carry-Forward Losses And Other Temporary Items Without Deferred Taxes Recognition
Utilization of carry-forward losses and other temporary items without deferred taxes recognition
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to withholding tax.
Effective Income Tax Rate Reconciliation, Withholding Tax
Withholding tax
Income Tax Disclosure Table
Income Tax Disclosure [Table]
Income Tax Disclosure Line Items
Income Tax Disclosure [Line Items]
TAXES ON INCOME
Amount of additions to the valuation allowance for deferred tax asset.
Deferred Tax Assets, Valuation Allowance, Additions During The Period
Additions to valuation allowance
Amount of reductions to the valuation allowance for deferred tax asset.
Deferred Tax Assets, Valuation Allowance, Reductions During The Period
Reductions to valuation allowance
Unrecognized Tax Benefits
Ending Balance
Beginning balance
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increase for tax position related to current year
Income Tax Contingency [Table]
Income Tax Jurisdiction [Axis]
Income Tax Jurisdiction [Domain]
Israel
UNITED STATES
Income Tax Contingency [Line Items]
Open Tax Year
Open tax year
Consolidated Entities [Axis]
Consolidated Entities [Domain]
Subsidiaries [Member]
Subsidiaries
Parent Company [Member]
Parent Company
Represents the tax rate thereafter years.
Tax Year Thereafter [Member]
Tax Year Thereafter
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Statutory income tax rate
Deferred Tax Liabilities, Deferred Expense, Capitalized Research and Development Costs
Deferred tax liability of research and development costs
Amortization period of cost capitalized for research and development cost, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.
Capitalized Research And Development Cost, Amortization Period
Amortization period research and development costs
Operating Loss Carryforwards
Schedule of Segment Reporting Information, by Segment [Table]
Segment Reporting Information [Line Items]
SEGMENT INFORMATION
Number of Operating Segments
Labor and Related Expense
Employee salaries and related expenses
Professional and Contract Services Expense
Sub-contractors expense
Segment Reporting, Other Segment Item, Amount
Other segment expenses
Segment Reporting, Other Segment Item, Composition, Description
Segment reporting description
Prepaid Expense and Other Assets, Current [Abstract]
Other assets:
Aggregate carrying amount, as of the balance sheet date, of current assets related to institutions. Current assets are expected to be realized or consumed within one year (or the normal operating cycle, if longer).
Other Assets, Institutions, Current
Institutions
Prepaid Expense, Current
Prepaid expenses
Aggregate carrying amount of current assets as of the balance sheet date, arising from sundry. Current assets are expected to be realized or consumed within one year (or the normal operating cycle, if longer).
Other Assets, Sundry, Current
Sundry
Employee-related Liabilities, Current
Payroll and related expenses
Interest Payable, Current
Interest payable
Accrued Vacation, Current
Provision for vacation
Accrued Liabilities, Current
Accrued expenses
Accrued Royalties, Current
Royalties payable
Taxes Payable, Current
Income tax payable
Carrying value as of the balance sheet date of the obligations incurred through that date and payable to customers. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Payable To Customer, Current
Payable to customer
Carrying value as of the balance sheet date of reserve for deductions from revenue.
Reserve For Deductions From Revenue Current
Sales reserve
Carrying value as of the balance sheet date of obligations incurred and payable to property and equipment suppliers. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accounts Payable, Property And Equipment Suppliers, Current
Property and equipment suppliers
Related Party Transaction [Table]
Related and Nonrelated Parties [Axis]
Related and Nonrelated Parties [Domain]
Related Party [Member]
Related Party
Director [Member]
Director
Related Party Transaction [Line Items]
Related Party Transaction, Amounts of Transaction
Compensation (including share based compensation) to the non-executive directors
Other General and Administrative Expense
Consulting fees
Subsequent Event [Table]
Subsequent Event Type [Axis]
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event
Pfizer Agreement
Pfizer Agreement [Member]
Represents information pertaining to supply and technology transfer agreement with Fiocruz.
Brazil Agreement with Fiocruz
Subsequent Event [Line Items]
Proceeds from Customers
Total proceeds from sale of products
Common Stock, Capital Shares Reserved for Future Issuance
Shares remain for sale
Class of Warrant or Right, Outstanding
Warrants and rights outstanding