UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date:	December 22, 2008

Accession Number:	0000950123-08-018029
Submission Type:	POS AM
CIK: 0001006281 Company Name: Protalix BioTherapeutics, Inc. File Number: 333-146919